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CD4+ T-cell responses to Epstein-Barr virus nuclear antigen EBNA1 in Chinese populations are highly focused on novel C-terminal domain-derived epitopes

Tsang, C. W. and Lin, X. and Gudgeon, N. H. and Taylor, G. S. and Jia, H. and Hui, E. P. and Chan, A. T. C. and Lin, C. K. and Rickinson, A. B. (2006) CD4+ T-cell responses to Epstein-Barr virus nuclear antigen EBNA1 in Chinese populations are highly focused on novel C-terminal domain-derived epitopes. Journal of Virology, 80 (16). pp. 8263-8266. ISSN 0022-538X

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URL of Published Version: http://dx.doi.org/10.1128/JVI.00400-06

Identification Number/DOI: 10.1128/JVI.00400-06

Epstein-Barr virus nuclear antigen EBNA1, the one viral protein uniformly expressed in nasopharyngeal carcinoma (NPC), represents a prime target for T-cell-based immunotherapy. However, little is known about the EBNA1 epitopes, particularly CD4 epitopes, presented by HLA alleles in Chinese people, the group at highest risk for NPC. We analyzed the CD4\(^+\) T-cell responses to EBNA1 in 78 healthy Chinese donors and found marked focusing on a small number of epitopes in the EBNA1 C-terminal region, including a DP5- restricted epitope that was recognized by almost half of the donors tested and elicited responses able to recognize EBNA1-expressing, DP5-positive target cells.

Type of Work:Article
Date:August 2006 (Publication)
School/Faculty:Schools (1998 to 2008) > School of Medicine
Department:CRUK Institute for Cancer Studies
Subjects:RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Institution:University of Birmingham
Copyright Holders:American Society for Microbiology
ID Code:1139
Refereed:YES
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