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High-throughput whole-genome sequencing to dissect the epidemiology of Acinetobacter baumannii isolates from a hospital outbreak

Lewis, T. and Loman, N. J. and Bingle, L. and Jumaa, P. and Weinstock, G.M. and Mortiboy, D. and Pallen, Mark J. (2010) High-throughput whole-genome sequencing to dissect the epidemiology of Acinetobacter baumannii isolates from a hospital outbreak. Journal of Hospital Infection, 75 (1). pp. 37-41. ISSN 01956701

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URL of Published Version: http://dx.doi.org/10.1016/j.jhin.2010.01.012

Identification Number/DOI: 10.1016/j.jhin.2010.01.012

Shared care of military and civilian patients has resulted in transmission of multidrug-resistant Acinetobacter baumannii (MDR-Aci) from military casualties to civilians. Current typing technologies have been useful in revealing relationships between isolates of A. baumannii but they are unable to resolve differences between closely related isolates from small-scale outbreaks, where chains of transmission are often unclear. In a recent hospital outbreak in Birmingham, six patients were colonised with MDR-Aci isolates indistinguishable using standard techniques. We used whole-genome sequencing to identify single nucleotide polymorphisms in these isolates, allowing us to discriminate between alternative epidemiological hypotheses in this setting.

Type of Work:Article
Date:2010 (Publication)
School/Faculty:Colleges (2008 onwards) > College of Life & Environmental Sciences
Department:School of Biosciences
Subjects:QH426 Genetics
QR180 Immunology
RA Public aspects of medicine
Institution:University of Birmingham
Copyright Holders:Elsevier, The authors
ID Code:1163
Refereed:YES
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