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Evaluation of liposomes coated with a pH responsive polymer

Barea, M.J. and Jenkins, M.J. and Gaber, M.H. and Bridson, R.H. (2010) Evaluation of liposomes coated with a pH responsive polymer. International Journal of Pharmaceutics, 402 (1-2). pp. 89-94. ISSN 03785173

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URL of Published Version: http://dx.doi.org/10.1016/j.ijpharm.2010.09.028

Identification Number/DOI: doi:10.1016/j.ijpharm.2010.09.028

Liposomes have been coated with the pH responsive polymer, Eudragit S100, and the formulation's potential for lower gastrointestinal (GI) targeting following oral administration assessed. Cationic liposomes were coated with the anionic polymer through simple mixing. The evolution of a polymer coat was studied using zeta potential measurements and laser diffraction size analysis. Further evidence of an association between polymer and liposome was obtained using light and cryo scanning electron microscopy. Drug release studies were carried out at pH 1.4, pH 6.3 and pH 7.8, representing the pH conditions of the stomach, small intestine and ileocaecal junction, respectively.

The polymer significantly reduced liposomal drug release at pH 1.4 and pH 6.3 but drug release was equivalent to the uncoated control at pH 7.8, indicating that the formulation displayed appropriate pH responsive release characteristics. While the coating layer was not able to withstand the additional challenge of bile salts this reinforces the importance of evaluating these types of formulations in more complex media.

Type of Work:Article
Date:2010 (Publication)
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:School of Chemical Engineering
Subjects:TA Engineering (General). Civil engineering (General)
TP Chemical technology
Institution:University of Birmingham
Copyright Holders:Elsevier
ID Code:1184
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