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Cardiovascular activity and the antibody response to vaccination

Phillips, Anna C. and Carroll, Douglas and Burns, Victoria E. and Drayson, Mark (2009) Cardiovascular activity and the antibody response to vaccination. Journal of Psychosomatic Research, 67 (1). pp. 37-43. ISSN 00223999

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URL of Published Version: http://dx.doi.org/10.1016/j.jpsychores.2008.12.002

Identification Number/DOI: doi:10.1016/j.jpsychores.2008.12.002

Objective: To examine the relationship between cardiovascular activity in response to acute psychological stress and the antibody response to vaccination.
Methods: Fifty-seven healthy participants were vaccinated with the trivalent influenza vaccine and meningococcal A+C polysaccharides. Antibody levels were measured at baseline and 5-weeks post-vaccination. Cardiovascular activity was measured at rest, during and following a mental arithmetic stress task in 54 participants.
Results: Participants demonstrating a four-fold increase in antibody titre to the A/Panama and B/Shangdong influenza strains and to meningococcal A showed greater blood pressure reactions toward the end of the acute stress task. In addition, there was some evidence of delayed diastolic blood pressure recovery in those who were responders to A/Panama and B/Shangdong influenza strains.
Conclusion: The present results suggest that heightened cardiovascular reactivity to stress and delayed recovery may not necessarily be detrimental to all aspects of health, and may be associated with an enhanced immune response to antigen challenge.

Type of Work:Article
Date:2009 (Publication)
School/Faculty:Colleges (2008 onwards) > College of Life & Environmental Sciences
Department:School of Sport and Exercise Sciences
Subjects:GV Recreation Leisure
R Medicine (General)
Institution:University of Birmingham
Copyright Holders:Elsevier
ID Code:1185
Refereed:YES
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