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Preliminary evidence that morning vaccination is associated with an enhanced antibody response in men

Phillips, Anna C. and Gallagher, Stephen and Carroll, Douglas and Drayson, Mark (2008) Preliminary evidence that morning vaccination is associated with an enhanced antibody response in men. Psychophysiology, 45 (4). pp. 663-666. ISSN 0048-5772

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URL of Published Version: http://dx.doi.org/10.1111/j.1469-8986.2008.00662.x

Identification Number/DOI: doi:10.1111/j.1469-8986.2008.00662.x

Variation in response to vaccination, particularly in vulnerable groups, provides a strong rationale for developing vaccine adjuvants. If there were consistent diurnal variation in immune response, this could inform a simple intervention for enhancing vaccine efficacy. Data from two studies are presented examining morning versus afternoon vaccine administration; in the first, hepatitis A vaccine was administered to young adults, and in the second, influenza vaccine to older community-based adults. Men, but not women, vaccinated in the morning mounted a better peak antibody response to both hepatitis A and the A/Panama influenza strain. These results indicate that it would be worthwhile testing this effect in a large randomized control trial with vaccination during time periods representing the extremes of hormonal and cytokine diurnal rhythms.

Type of Work:Article
Date:2008 (Publication)
School/Faculty:Colleges (2008 onwards) > College of Life & Environmental Sciences
Department:School of Sport and Exercise Sciences
Subjects:GV Recreation Leisure
R Medicine (General)
Institution:University of Birmingham
Copyright Holders:Wiley Blackwell
ID Code:1196
Refereed:YES
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