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Social support is positively associated with the immunoglobulin M response to vaccination with pneumococcal polysaccharides

Phillips, Anna C. and Gallagher, Stephen and Carroll, Douglas and Drayson, Mark (2008) Social support is positively associated with the immunoglobulin M response to vaccination with pneumococcal polysaccharides. Biological Psychology, 78 (2). pp. 211-215. ISSN 0301-0511

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URL of Published Version: http://dx.doi.org/10.1111/j.1469-8986.2008.00662.x

Identification Number/DOI: http://dx.doi.org/10.1016/j.biopsycho.2008.01.001

Evidence shows that psychosocial factors are associated with immunoglobulin G response to medical vaccinations. As yet, there are no reports of whether the earlier immunoglobulinMresponse is similarly susceptible. This study examined the association between psychological stress, social support and the immunoglobulin M response to vaccination with pneumococcal capsular polysaccharides. Stressful life events in the previous year and customary social support were measured by standard questionnaires at baseline in 74 healthy students (41 females). The response to five common pneumococcal serotypes was assessed at baseline and 5 days following vaccination. Social support, particularly tangible social support, was positively associated with the antibody response to two of five serotypes, after controlling for baseline titre. These associations survived adjustment for demographics and health behaviours. There was no association between life events stress and immunoglobulin M response. It appears that psychosocial factors affect both the immunoglobulinM and immunoglobulin G responses to vaccination.

Type of Work:Article
Date:2008 (Publication)
School/Faculty:Colleges (2008 onwards) > College of Medical & Dental Sciences
Department:School of Sport and Exercise Sciences
Subjects:BF Psychology
GV Recreation Leisure
R Medicine (General)
Institution:University of Birmingham
Copyright Holders:Elsevier
ID Code:1197
Refereed:YES
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