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Cytomegalovirus is associated with depression and anxiety in older adults

Phillips, Anna C. and Carroll, Douglas and Khan, Naeem and Moss, Paul (2008) Cytomegalovirus is associated with depression and anxiety in older adults. Brain, Behavior, and Immunity, 22 (1). pp. 52-55. ISSN 08891591

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URL of Published Version: http://dx.doi.org/10.1016/j.bbi.2007.06.012

Identification Number/DOI: doi:10.1016/j.bbi.2007.06.012

Infection with cytomegalovirus (CMV), a β-herpesvirus, is common within the population. Although asymptomatic, infection is associated with increased serum concentrations of cytokines such as TNFα and IL-6, which are also related to mood and wellbeing. The present study examined whether infection with CMV was associated with mood in a community-based sample of olderadults. Blood samples and scores on the General Health Questionnaire were available for 137 participants. Serum was analysed for the presence of CMV-specific IgG and the antibody titre was used as an indirect measure of viral load. The majority of the participants (66%) were CMV-seropositive and seropositive status was not associated with psychological morbidity. However, within the CMV-positive group, individuals with higher CMV-specific antibody titres were more likely to be depressed, anxious, and suffer more overall psychological morbidity. This association could be mediated by the impact of affect-moderating cytokines secreted through the CMV-specific immune response.

Type of Work:Article
Date:2008 (Publication)
School/Faculty:Colleges (2008 onwards) > College of Life & Environmental Sciences
Department:School of Sport and Exercise Sciences
Subjects:GV Recreation Leisure
R Medicine (General)
Institution:University of Birmingham
Copyright Holders:Elsevier
ID Code:1201
Refereed:YES
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