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Electron Detachment Dissociation,and Collision-Induced Dissociation of Polyamidoamine (PAMAM) Dendrimer Ions with Amino, Amidoethanol, and Sodium Carboxylate Surface Groups

Kaczorowska, Malgorzata A. and Cooper, Helen J. (2008) Electron Detachment Dissociation,and Collision-Induced Dissociation of Polyamidoamine (PAMAM) Dendrimer Ions with Amino, Amidoethanol, and Sodium Carboxylate Surface Groups. Journal of the American Society for Mass Spectrometry, 19 (9). pp. 1312-1319.

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URL of Published Version: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2571976

Identification Number/DOI: 10.1016/j.jasms.2008.06.016

Here, we investigate the effect of the structure (generation) and nature of the surface groups of different polyamidoamine (PAMAM) dendrimers on electron-mediated dissociation, either electron capture dissociation (ECD) or electron detachment dissociation (EDD), and compare the fragmentation with that observed in collision-induced dissociation (CID). ECD and EDD of the PAMAM dendrimers esulted in simple mass spectra, which are straightforward to interpret, whereas CID produced complex mass spectra. The results show that electron-mediated dissociation (ECD and EDD) of PAMAM dendrimers does not depend on the nature of the surface group but tends to occur within the innermost generations. CID of the PAMAM dendrimers showed a strong dependence on the nature of the surface group and occurred mostly in the outer generation. The results demonstrate the potential utility of ECD and EDD as a tool for the structural analysis of PAMAM dendrimers.

Type of Work:Article
Date:August 2008 (Publication)
School/Faculty:Schools (1998 to 2008) > School of Biosciences
Department:Structural Biology
Subjects:Q Science (General)
Institution:University of Birmingham
Copyright Holders:Elsevier
ID Code:124
Refereed:YES
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