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Cognitive ability in early adulthood is associated with systemic inflammation in middle age: The Vietnam experience study

Phillips, Anna C. and Batty, G. David and van Zanten, Jet J.C.S. Veldhuijzen and Mortensen, Laust H. and Deary, Ian J. and Calvin, Catherine M. and Carroll, Douglas (2011) Cognitive ability in early adulthood is associated with systemic inflammation in middle age: The Vietnam experience study. Brain, Behavior, and Immunity, 25 (2). pp. 298-301. ISSN 08891591

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URL of Published Version: http://dx.doi.org/10.1016/j.bbi.2010.09.022

Identification Number/DOI: doi:10.1016/j.bbi.2010.09.022

We examined the prospective association between cognitive ability in early adulthood and erythrocyte sedimentation rate, a marker of inflammation, in middle age. Participants were 4256 male Vietnam era US veterans. Data on cognitive ability, assessed by the Army General Technical Test, ethnicity, and place of service were extracted from enlistment files. Smoking behaviour, alcohol consumption, basic socio-demographics, and whether participants suffered from a physician diagnosed chronic disease were determined by telephone interview in middle-age in 1985. Erythrocyte sedimentation rate, cholesterol, blood pressure, height, and weight were measured at a 3-day medical examination in 1986. In linear regression models that adjusted for age and then additionally for circumstantial, socio-demographic, lifestyle, and health factors, poor cognitive ability in early adulthood was associated with greater erythrocyte sedimentation rate in middle age, β = -.09. Thus, it would appear that not only does systemic inflammation affect cognition, but also that poor cognitive ability earlier in life increases the risk of developing inflammation.

Type of Work:Article
Date:2011 (Publication)
School/Faculty:Colleges (2008 onwards) > College of Life & Environmental Sciences
Department:School of Sport and Exercise Sciences
Subjects:BF Psychology
GV Recreation Leisure
Institution:University of Birmingham
Copyright Holders:Elsevier
ID Code:1248
Refereed:YES
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