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Lymphocyte cell counts in middle age are positively associated with subsequent all-cause and cardiovascular mortality

Phillips, Anna C. and Carroll, Douglas and Gale, Catharine R. and Drayson, Mark T. and Batty, G. David (2011) Lymphocyte cell counts in middle age are positively associated with subsequent all-cause and cardiovascular mortality. QJM, 104 (4). pp. 319-324. ISSN 1460-2725

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URL of Published Version: http://dx.doi.org/10.1093/qjmed/hcq199

Identification Number/DOI: doi:10.1093/qjmed/hcq199

Background: There is an association between higher white blood cell counts and all-cause and cardiovascular disease mortality. However, little is known about the prognostic significance of circulating lymphocyte and lymphocyte subset numbers. Aims: The present study examined the association between T, CD4,CD8,and B cell numbers, and the CD4:CD8 ratio, and all-cause and cardiovascular disease mortality. Methods: Lymphocyte and lymphocyte subset numbers were measured by flow cytometry in a cohort of 4256 male middle-aged Vietnam-era US veterans. Mortality was tracked for 15 years and cause of death was determined from death certificates. Results: In fully-adjusted survival analyses, high circulating T cells numbers were associated with increased risk of both all-cause (HR=1.75,95%CI 1.15 – 2.66) and cardiovascular (HR = 3.57, 95%CI 1.53 – 8.33) mortality. The former association appeared to reflect an effect for high CD8 cells numbers, the latter an effect for high CD4 cell numbers. For all-cause mortality, a high CD4:CD8 ratio was protective (HR = 0.58, 95%CI 0.41 – 0.81) Cardiovascular mortality was also predicted by high B cells numbers (HR = 1.87, 95%CI 1.10 – 3.17). Conclusion: Circulating lymphocyte and lymphocyte subset numbers may have substantial prognostic significance for both all-cause and cardiovascular disease mortality

Type of Work:Article
Date:2011 (Publication)
School/Faculty:Colleges (2008 onwards) > College of Life & Environmental Sciences
Department:School of Sport and Exercise Sciences
Subjects:GV Recreation Leisure
R Medicine (General)
Institution:University of Birmingham
Copyright Holders:Oxford University Press
ID Code:1252
Refereed:YES
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