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Cortisol, DHEAS, their ratio and the metabolic syndrome: evidence from the Vietnam Experience Study

Phillips, Anna C. and Carroll, Douglas and Gale, Catharine R. and Lord, Janet M. and Arlt, Wiebke and Batty, G. David (2010) Cortisol, DHEAS, their ratio and the metabolic syndrome: evidence from the Vietnam Experience Study. European Journal of Endocrinology, 162 (5). pp. 919-923. ISSN 0804-4643

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URL of Published Version: http://dx.doi.org/10.1530/EJE-09-1078

Identification Number/DOI: doi:10.1530/EJE-09-1078

Objectives: The aim of these analyses was to examine the association between cortisol, dehydroepiandrosterone sulphate (DHEAS), and the cortisol:DHEAS ratio and mortality.

Design: This was a prospective cohort analysis. Methods: Participants were 4255 Vietnam era US army veterans. From military service files, telephone interviews, and a medical examination, occupational, socio-demographic, and health data were collected. Contemporary morning fasted cortisol and DHEAS concentrations were determined. Mortality was tracked over the subsequent 15 years. The outcomes were all-cause, cardiovascular disease, cancer, other medical mortality and external causes of death. Cox proportional hazard models were tested, first with adjustment for age and then additionally adjusting for a range of candidate confounders. Results: In general, cortisol concentrations did not show an association with all-cause or cause-specific mortality. However, in age- and fully-adjusted analyses, DHEAS was negatively related to all-cause, all cancers, and other medical mortality; high DHEAS concentrations were protective. The cortisol:DHEAS ratio was also associated with these outcomes in both age- and fully-adjusted models; the higher the ratio the greater the risk of death. Conclusions: DHEAS was negatively, and the ratio of cortisol to DHEAS was positively associated with all-cause, cancer, and other medical cause mortality. Further experimental study is needed to elucidate the mechanisms involved in these relationships.

Type of Work:Article
Date:2010 (Publication)
School/Faculty:Colleges (2008 onwards) > College of Life & Environmental Sciences
Department:School of Sport and Exercise Sciences
Subjects:BF Psychology
Institution:University of Birmingham
Copyright Holders:Taylor and Francis
ID Code:1320
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