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Autophagy and the Liver

Bhogal, Ricky Harminder and Afford, Simon C (2013) Autophagy and the Liver. In: Autophagy - A Double-Edged Sword - Cell Survival or Death? InTech.

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URL of Published Version: http://dx.doi.org/10.5772/55585

Identification Number/DOI: doi:10.5772/55585

Autophagy is a cellular process that involves lysosomal degradation and recycling of intracellular organelles and proteins to maintain energy homeostasis during times of cellular stress [1]. It also serves to remove damaged cellular components such as mitochondria and long-lived proteins. Autophagy is catabolic mechanism and although hepatic autophagy performs the standard functions of degrading damaged organelles/aggregated proteins and regulating cell death it also regulates lipid accumulation within the liver. Autophagy can be divided into three distinct sub-groups that are discussed below. This chapter focuses upon the role of autophagy in a variety of liver diseases including hepatocellular carcinoma (HCC) and viral hepatitis. The increased understanding of the cellular machinery regulating autophagy within the liver may foster the development of therapeutic strategies that will ultimately help treat liver disease.

Type of Work:Book Section
Date:2013 (Publication)
School/Faculty:Colleges (2008 onwards) > College of Medical & Dental Sciences
Department:Centre for Liver Research
Subjects:RC Internal medicine
Institution:University of Birmingham
Copyright Holders:Intech
ID Code:1348
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