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Synchronization and desynchronization in epilepsy: controversies and hypotheses

Jiruska, P. and de Curtis, M. and Jefferys, John G R and Schevon, C. A. and Schiff, S. J. and Schindler, K (2013) Synchronization and desynchronization in epilepsy: controversies and hypotheses. The Journal of Physiology, 591 (4). pp. 787-797. ISSN 0022-3751

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URL of Published Version: http://dx.doi.org/10.1113/jphysiol.2012.239590

Identification Number/DOI: doi:10.1113/jphysiol.2012.239590

synchronization of large neuronal populations leading to a hypersynchronous state. Recent evidence showed that epileptiform phenomena, particularly seizures, result from complex interactions between neuronal networks characterized by heterogeneity of neuronal firing and
dynamical evolution of synchronization. Desynchronization is often observed preceding seizures or during their early stages; in contrast, high levels of synchronization observed towards the end of seizures may facilitate termination. In this review we discuss cellular and network mechanisms responsible for such complex changes in synchronization. Recent work has identified cell-type-specific inhibitory and excitatory interactions, the dichotomy between neuronal firing and the non-local measurement of local field potentials distant to that firing, and the reflection of the neuronal dark matter problem in non-firing neurons active in seizures. These recent advances have challenged long-established views and are leading to a more rigorous and realistic understanding of the pathophysiology of epilepsy.

Type of Work:Article
Date:2013 (Publication)
School/Faculty:Colleges (2008 onwards) > College of Medical & Dental Sciences
Department:School of Clinical and Experimental Medicine
Subjects:R Medicine (General)
Institution:University of Birmingham
Copyright Holders:Wiley-Blackwell
ID Code:1363
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