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Mathematical model of the Lux luminescence system in the terrestrial bacterium Photorhabdus luminescens.

Welham, Patricia A and Stekel, Dov J (2009) Mathematical model of the Lux luminescence system in the terrestrial bacterium Photorhabdus luminescens. Molecular bioSystems, 5 (1). pp. 68-76. ISSN 1742-2051

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Identification Number/DOI: 10.1039/B812094C

A mathematical model of the Lux luminescence system, governed by the operon luxCDABE in the terrestrial bacterium Photorhabdus luminescens, was constructed using a set of coupled ordinary differential equations. This model will have value in the interpretation of Lux data when used as a reporter in time-course gene expression experiments. The system was tested on time series and stationary data from published papers and the model is in good agreement with the published data. Metabolic control analysis demonstrates that control of the system lies mainly with the aldehyde recycling pathway (LuxE and LuxC). The rate at which light is produced in the steady state model shows a low sensitivity to changes in kinetic parameter values to those measured in other species of luminescent bacteria, demonstrating the robustness of the Lux system.

Type of Work:Article
Date:January 2009 (Publication)
School/Faculty:Colleges (2008 onwards) > College of Life & Environmental Sciences
Department:School of Biosciences
Subjects:QA Mathematics
QD Chemistry
QH301 Biology
Institution:University of Birmingham
Copyright Holders:Royal Society of Chemistry
ID Code:147
Refereed:YES
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