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Disruption of State Estimation in the Human Lateral Cerebellum

Miall, R. Chris and Christensen, Lars O. D. and Cain, Owen and Stanley, James (2007) Disruption of State Estimation in the Human Lateral Cerebellum. PLoS Biology. ISSN 1544-9173

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URL of Published Version: http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050316

Identification Number/DOI: doi:10.1371/journal.pbio.0050316

The cerebellum has been proposed to be a crucial component in the state estimation process that combines information from motor efferent and sensory afferent signals to produce a representation of the current state of the
motor system. Such a state estimate of the moving human arm would be expected to be used when the arm is rapidly
and skillfully reaching to a target. We now report the effects of transcranial magnetic stimulation (TMS) over the
ipsilateral cerebellum as healthy humans were made to interrupt a slow voluntary movement to rapidly reach towards a visually defined target. Errors in the initial direction and in the final finger position of this reach-to-target movement were significantly higher for cerebellar stimulation than they were in control conditions. The average directional errors in the cerebellar TMS condition were consistent with the reaching movements being planned and initiated from an estimated hand position that was 138 ms out of date. We suggest that these results demonstrate that the cerebellum is responsible for estimating the hand position over this time interval and that TMS disrupts this state estimate.

Type of Work:Article
Date:27 November 2007 (Publication)
School/Faculty:Schools (1998 to 2008) > School of Psychology
Department:Motor Neuroscience
Subjects:BF Psychology
Institution:University of Birmingham
Copyright Holders:Public Library of Science
ID Code:157
Refereed:YES
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