Bailey, Christopher M and Sweet, Steve M M and Cunningham, Debbie L and Zeller, Martin and Heath, John K and Cooper, Helen J. (2009) SLoMo: automated site localization of modifications from ETD/ECD mass spectra. Journal of proteome research, 8 (4). pp. 1965-71. ISSN 1535-3893
Identification Number/DOI: 10.1021/pr800917p
Recently, software has become available to automate localization of phosphorylation sites from CID data and to assign associated confidence scores. We present an algorithm, SLoMo (Site Localization of Modifications), which extends this capability to ETD/ECD mass spectra. Furthermore, SLoMo caters for both high and low resolution data and allows for site-localization of any UniMod post-translational modification. SLoMo accepts input data from a variety of formats (e.g., Sequest, OMSSA). We validate SLoMo with high and low resolution ETD, ECD, and CID data.
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