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Left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging

Yousef, Zaheer R and Foley, Paul WX and Khadjooi, Kayvan and Chalil, Shajil and Sandman, Harald and Mohammed, Noor UH and Leyva, Francisco (2009) Left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging. BMC Cardiovascular Disorders, 9 (1). p. 37. ISSN 1471-2261

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URL of Published Version: http://dx.doi.org/10.1186/1471-2261-9-37

Identification Number/DOI: 10.1186/1471-2261-9-37

Background: It is apparent that despite lack of family history, patients with the morphological characteristics of left ventricular non-compaction develop arrhythmias, thrombo-embolism and left ventricular dysfunction. METHODS: Forty two patients, aged 48.7 +/- 2.3 yrs (mean +/- SEM) underwent cardiovascular magnetic resonance (CMR) for the quantification of left ventricular volumes and extent of non-compacted (NC) myocardium. The latter was quantified using planimetry on the two-chamber long axis LV view (NC area). The patients included those referred specifically for CMR to investigate suspected cardiomyopathy, and as such is represents a selected group of patients. RESULTS: At presentation, 50% had dyspnoea, 19% chest pain, 14% palpitations and 5% stroke. Pulmonary embolism had occurred in 7% and brachial artery embolism in 2%. The ECG was abnormal in 81% and atrial fibrillation occurred in 29%. Transthoracic echocardiograms showed features of NC in only 10%. On CMR, patients who presented with dyspnoea had greater left ventricular volumes (both p < 0.0001) and a lower left ventricular ejection fraction (LVEF) (p < 0.0001) than age-matched, healthy controls. In patients without dyspnoea (n = 21), NC area correlated positively with end-diastolic volume (r = 0.52, p = 0.0184) and end-systolic volume (r = 0.56, p = 0.0095), and negatively with EF (r = -0.72, p = 0.0001). CONCLUSION: Left ventricular non-compaction is associated with dysrrhythmias, thromboembolic events, chest pain and LV dysfunction. The inverse correlation between NC area and EF suggests that NC contributes to left ventricular dysfunction.

Type of Work:Article
Date:2009 (Publication)
School/Faculty:Colleges (2008 onwards) > College of Medical & Dental Sciences
Department:Primary Care
Subjects:RC Internal medicine
Institution:University of Birmingham
Copyright Holders:BMC
ID Code:324
Refereed:YES
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