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Calciphylaxis following kidney transplantation: a case report

Hanvesakul, Rajesh and Silva, Michael A and Hejmadi, Rahul and Mellor, Steve and Ready, Andrew R and Cockwell, Paul and Inston, Nicholas (2009) Calciphylaxis following kidney transplantation: a case report. Journal of Medical Case Reports, 3 (1). p. 9297. ISSN 1752-1947

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URL of Published Version: http://dx.doi.org/10.1186/1752-1947-3-9297

Identification Number/DOI: doi:10.1186/1752-1947-3-9297

Introduction: Calciphylaxis occurring after kidney transplantation is rare and rarely reported. It results in chronic non-healing wounds and is associated with a poor prognosis and is often fatal. We present a case of proximal lower limb calciphylaxis that occurred early after kidney transplantation. The patient had no classic associated risk factors. He had previously had a total parathyroidectomy but had normal serum calcium-phosphate product and parathyroid hormone levels. The clinical outcome of this case was favorable and highlights some fundamental issues relating to management.

Case prsentation: A 70-year-old British Caucasian man with end-stage renal failure secondary to IgA nephropathy presented six months post kidney transplantation with cutaneous calciphylaxis lesions involving the medial aspect of the thigh bilaterally.

Conclusion: To the best of our knowledge, this is the first reported case of rapid onset cutaneous calciphylaxis occurring soon after kidney transplantation that was associated with a favorable outcome. Cutaneous calciphylaxis lesions should be promptly managed with meticulous wound care, antimicrobial therapy and the correction of calcium-phosphate product where indicated.

Type of Work:Article
Date:2009 (Publication)
School/Faculty:Colleges (2008 onwards) > College of Medical & Dental Sciences
Department:School of Medicine
Subjects:RA Public aspects of medicine
Institution:University of Birmingham
Copyright Holders:BMC
ID Code:331
Refereed:YES
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