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Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy

Jiruska, Premysl and Finnerty, Gerald T and Powell, Andrew D and Lofti, Noosheen and Cmejla, Roman and Jefferys, John G R (2010) Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy. Brain, 133 (5). pp. 1380-1390. ISSN 0006-8950

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URL of Published Version: http://brain.oxfordjournals.org/cgi/reprint/133/5/1380

Identification Number/DOI: 10.1093/brain/awq070

High-frequency cortical activity, particularly in the 250–600 Hz (fast ripple) band, has been implicated in playing a crucial role in epileptogenesis and seizure generation. Fast ripples are highly specific for the seizure initiation zone. However, evidence for the association of fast ripples with epileptic foci depends on animal models and human cases with substantial lesions in the form of hippocampal sclerosis, which suggests that neuronal loss may be required for fast ripples. In the present work, we tested whether cell loss is a necessary prerequisite for the generation of fast ripples, using a non-lesional model of temporal lobe epilepsy that lacks hippocampal sclerosis. The model is induced by unilateral intrahippocampal injection of tetanus toxin. Recordings from the hippocampi of freely-moving epileptic rats revealed high-frequency activity (4100 Hz), including fast ripples. High-frequency activity was present both during interictal discharges and seizure onset. Interictal fast ripples proved a significantly more reliable marker of the primary epileptogenic zone than the presence of either interictal discharges or ripples (100–250 Hz). These results suggest that fast ripple activity should be considered for its potential value in the pre-surgical workup of non-lesional temporal lobe epilepsy.

Type of Work:Article
Date:2010 (Publication)
School/Faculty:Colleges (2008 onwards) > College of Medical & Dental Sciences
Department:School of Clinical and Experiment Medicine
Subjects:RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
QP Physiology
Institution:University of Birmingham, Institute of Psychiatry, Imperial College London, Czech Technical University
Copyright Holders:The Authors
ID Code:358
Refereed:YES
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