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Antibody response to vaccination and psychosocial stress in humans:relationships and mechanisms.

Burns, Victoria E and Carroll, Douglas and Ring, Christopher and Drayson, Mark T. (2003) Antibody response to vaccination and psychosocial stress in humans:relationships and mechanisms. Vaccine, 21 (19-20). pp. 2523-2534. ISSN 0264-410X

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Identification Number/DOI: http://dx.doi.org/10.1016/S0264-410X(03)00041-0

The purpose of this review is to determine the effects of psychosocial stress on antibody response to vaccination in humans, consider possible mechanisms, and identify agenda for future research. Studies of the association between stress and vaccination response in humans were reviewed. There is evidence of a negative association between stress and antibody response to vaccination, which is most apparent with thymus-dependent vaccines and when measured at extended times after vaccination. Preliminary findings implicate the hypothalamic-pituitary-adrenal axis and sympathetic nervous system as potential mechanisms, although a role for unhealthy behaviours cannot be discounted at this stage. Results to date are sufficiently indicative to direct future research to untangling their theoretical ramifications, as well as realising their clinical implications.

Type of Work:Article
Date:2003 (Publication)
School/Faculty:Schools (1998 to 2008) > School of Sport & Exercise Science
Department:Sports and Exercise Science
Keywords:Antibody response to immunisation; psychosocial stress; psychoneuroimmunology
Subjects:QR180 Immunology
QR Microbiology
Institution:University of Birmingham
Copyright Holders:Elsevier
ID Code:4
Refereed:YES
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