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Primary hepatocytes as targets for hepatitis C virus replication

Farquhar, M J and McKeating, Jane A (2008) Primary hepatocytes as targets for hepatitis C virus replication. Journal of viral hepatitis, 15 (12). pp. 849-54. ISSN 1365-2893

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Much of our current understanding of hepatitis C virus (HCV) replication has hailed from the use of a small number of cloned viral genomes and transformed hepatoma cell lines. Recent evidence suggests that lipoproteins play a key role in the HCV life cycle and virus particles derived from the sera of infected patients exist in association with host lipoproteins. This report will review the literature on HCV replication in primary hepatocytes and transformed cell lines, focusing largely on host factors defining particle entry.

Type of Work:Article
Date:2008 (Publication)
School/Faculty:Colleges (2008 onwards) > College of Medical & Dental Sciences
Department:Immunity and Infection
Subjects:R Medicine (General)
QR355 Virology
QR180 Immunology
QR Microbiology
Institution:University of Birmingham
Copyright Holders:Blackwell Publishing Ltd
ID Code:469
Refereed:YES
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