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Hepatitis C virus entry and neutralization.

Stamataki, Zania and Grove, Joe and Balfe, Peter and McKeating, Jane A (2008) Hepatitis C virus entry and neutralization. Clinics in liver disease, 12 (3). 693-712, x. ISSN 1089-3261

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Identification Number/DOI: 10.1016/j.cld.2008.03.008

The processes of hepatitis C virus (HCV) entry and antibody-mediated neutralization are intimately linked. The high frequency of neutralizing antibodies (nAbs) that inhibit E2-CD81 interaction(s) suggests that this is a major target for the humoral immune response. The observation that HCV can transmit to naive cells by means of CD81-dependent and -independent routes in vitro awaits further investigation to assess the significance in vivo but may offer new strategies for HCV to escape nAbs. The identification of claudins in the entry process highlights the importance of cell polarity in defining routes of HCV entry and release, with recent experiments suggesting a polarized route of viral entry into cells in vitro. In this review, the authors summarize the current understanding of the mechanism(s) defining HCV entry and the role of nAbs in controlling HCV replication.

Type of Work:Article
Date:2008 (Publication)
School/Faculty:Schools (1998 to 2008) > School of Medicine
Department:Immunity and Infection
Subjects:R Medicine (General)
QR355 Virology
QR180 Immunology
QR Microbiology
Institution:University of Birmingham
Copyright Holders:Elsevier Ltd.
ID Code:473
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