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Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge.

Law, Mansun and Maruyama, Toshiaki and Lewis, Jamie and Giang, Erick and Tarr, Alexander W and Stamataki, Zania and Gastaminza, Pablo and Chisari, Francis V and Jones, Ian M and Fox, Robert I and Ball, Jonathan K and McKeating, Jane A and Kneteman, Norman M and Burton, Dennis R (2008) Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge. Nature medicine, 14 (1). pp. 25-7. ISSN 1546-170X

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Identification Number/DOI: 10.1038/nm1698

A major problem in hepatitis C virus (HCV) immunotherapy or vaccine design is the extreme variability of the virus. We identified human monoclonal antibodies (mAbs) that neutralize genetically diverse HCV isolates and protect against heterologous HCV quasispecies challenge in a human liver-chimeric mouse model. The results provide evidence that broadly neutralizing antibodies to HCV protect against heterologous viral infection and suggest that a prophylactic vaccine against HCV may be achievable.

Type of Work:Article
Date:2008 (Publication)
School/Faculty:Schools (1998 to 2008) > School of Medicine
Department:Immunity and Infection
Subjects:R Medicine (General)
QR355 Virology
QR180 Immunology
QR Microbiology
Institution:University of Birmingham
Copyright Holders:Nature Publishing Group
ID Code:478
Refereed:YES
Local Holdings:
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