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Neutralizing antibody response during acute and chronic hepatitis C virus infection

Logvinoff, Carine and Major, M E and Oldach, D and Heyward, S and Talal, A and Balfe, Peter and Feinstone, S M and Alter, H and Rice, C M and McKeating, Jane A (2004) Neutralizing antibody response during acute and chronic hepatitis C virus infection. Proceedings of the National Academy of Sciences of the United States of America, 101 (27). pp. 10149-54. ISSN 0027-8424

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Identification Number/DOI: 10.1073/pnas.0403519101

Little is known about the role of Abs in determining the outcome of hepatitis C virus (HCV) infection. By using infectious retroviral pseudotypes bearing HCV glycoproteins, we measured neutralizing Ab (nAb) responses during acute and chronic HCV infection. In seven acutely infected health care workers, only two developed a nAb response that failed to associate with viral clearance. In contrast, the majority of chronically infected patients had nAbs. To determine the kinetics of strain-specific and crossreactive nAb emergence, we studied patient H, the source of the prototype genotype 1a H77 HCV strain. An early weak nAb response, specific for the autologous virus, was detected at seroconversion. However, neutralization of heterologous viruses was detected only between 33 and 111 weeks of infection. We also examined the development of nAbs in 10 chimpanzees infected with H77 clonal virus. No nAb responses were detected in three animals that cleared virus, whereas strain-specific nAbs were detected in six of the seven chronically infected animals after approximately 50 weeks of infection. The delayed appearance of high titer crossreactive nAbs in chronically infected patients suggests that selective mechanism(s) may operate to prevent the appearance of these Abs during acute infection. The long-term persistence of these nAbs in chronically infected patients may regulate viral replication.

Type of Work:Article
Date:2004 (Publication)
School/Faculty:Schools (1998 to 2008) > School of Medicine
Department:Immunity and Infection
Subjects:R Medicine (General)
QR355 Virology
QR180 Immunology
QR Microbiology
Institution:University of Birmingham
Copyright Holders:The National Academy of Sciences of the USA
ID Code:496
Refereed:YES
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