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Is the abundance of Faecalibacterium prausnitzii relevant to Crohn's disease?

Jia, Wenjing and Whitehead, Rebekah N. and Griffiths, Lesley and Dawson, Claire and Waring, Rosemary H. and Ramsden, David B. and Hunter, John O. and Cole, Jeffrey A. (2010) Is the abundance of Faecalibacterium prausnitzii relevant to Crohn's disease? FEMS Microbiology Letters, 310 (2). p. 138. ISSN 03781097

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URL of Published Version: http://dx.doi.org/10.1111/j.1574-6968.2010.02057.x

Identification Number/DOI: doi:10.1111/j.1574-6968.2010.02057.x

Reports that bacteria within the Firmicutes phylum, especially the species Faecalibacterium prausnitzii, are less abundant in Crohn’s disease (CD) patients and supernatants from cultures of this bacterium are anti-inflammatory prompted the investigation of the possible correlations between the abundance of F.prausnitzii and the response to treatment in patients with gut diseases and healthy controls. In a randomized, double-blind trial, faeces were collected from healthy volunteers, and from patients with active CD, ulcerative colitis (UC) and irritable bowel syndrome before and after treatment. The levels of F. prausnitzii DNA in faecal suspensions were determined by PCR. Treatment by an elemental diet was effective, resulting in decreases in both the Harvey and Bradshaw index (P<0.001) and the concentrations of serum C-reactive protein (P<0.05). The total levels of F. prausnitzii in faecal samples from CD patients at presentation were lower than those in the other groups both before and after the treatment. There was no correlation between F. prausnitzii abundance and the severity of CD before treatment. Clinical improvement unexpectedly correlated with a significant decrease in the abundance of F. prausnitzii, especially the A2-165 subgroup (P<0.05). Our data suggest that a paucity of F. prausnitzii in the gastrointestinal microbial communities is likely to be a minor aetiological factor in CD: recovery following elemental diet is attributed to lower levels of gut flora.

Type of Work:Article
Date:2010 (Publication)
School/Faculty:Colleges (2008 onwards) > College of Life & Environmental Sciences
Department:School of Biosciences
Subjects:QR Microbiology
Institution:University of Birmingham
Copyright Holders:Wiley-Blackwell
ID Code:563
Refereed:YES
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