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Systematic review: the diagnosis and staging of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.

Dowman, J K and Tomlinson, J W and Newsome, P N (2011) Systematic review: the diagnosis and staging of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Alimentary pharmacology & therapeutics, 33 (5). pp. 525-40. ISSN 1365-2036

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Identification Number/DOI: 10.1111/j.1365-2036.2010.04556.x

Background: Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent cause of liver disease in Western countries. The development of non-alcoholic steatohepatitis (NASH) and fibrosis identifies an at-risk group with increased risk of cardiovascular and liver-related deaths. The identification and management of this at-risk group remains a clinical challenge.

Aim: To perform a systematic review of the established and emerging strategies for the diagnosis and staging of NAFLD.

Methods: Relevant research and review articles were identified by searching PubMed, MEDLINE and EMBASE.
Results: There has been a substantial development of non-invasive risk scores, biomarker panels and radiological modalities to identify at-risk patients with NAFLD without recourse to liver biopsy on a routine basis. These modalities and algorithms have improved significantly in their diagnosis and staging of fibrosis and NASH in patients with NAFLD, and will likely impact on the number of patients undergoing liver biopsy.

Conclusions: Staging for NAFLD can now be performed by a combination of radiological and laboratory techniques, greatly reducing the requirement for invasive liver biopsy.

Type of Work:Article
Date:2011 (Publication)
School/Faculty:Colleges (2008 onwards) > College of Medical & Dental Sciences
Department:Centre for Liver Research
Subjects:RC Internal medicine
RA Public aspects of medicine
Institution:University of Birmingham
Copyright Holders:Wiley-Blackwell
ID Code:564
Refereed:YES
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