Rowan, Mark (2011) Effects of compensation, connectivity and tau in a computational model of Alzheimer's Disease. Proceedings of the International Joint Conference on Neural Networks.
| Identification Number/DOI: 10.1109/IJCNN.2011.6033268 This work updates an existing, simplistic computational model of Alzheimer's Disease (AD) to investigate the behaviour of synaptic compensatory mechanisms in neural networks with small-world connectivity, and varying methods of calculating compensation. It additionally introduces a method for simulating tau neurofibrillary pathology, resulting in a more dramatic damage profile. Small-world connectivity is shown to have contrasting effects on capacity, retrieval time, and robustness to damage, whilst the use of more easily-obtained remote memories rather than recent memories for synaptic compensation is found to lead to rapid network damage. |
| Type of Work: | Article |
|---|---|
| Date: | 01 August 2011 (Publication) |
| School/Faculty: | Colleges (2008 onwards) > College of Engineering & Physical Sciences |
| Department: | Department of Computer Science |
| Subjects: | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry QA75 Electronic computers. Computer science |
| Institution: | University of Birmingham |
| Copyright Holders: | Institute of Electrical and Electronics Engineers |
| ID Code: | 745 |
| Refereed: | YES |
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