Rowan, Mark (2011) Effects of compensation, connectivity and tau in a computational model of Alzheimer's Disease. Proceedings of the International Joint Conference on Neural Networks.
Identification Number/DOI: 10.1109/IJCNN.2011.6033268
This work updates an existing, simplistic computational model of Alzheimer's Disease (AD) to investigate the behaviour of synaptic compensatory mechanisms in neural networks with small-world connectivity, and varying methods of calculating compensation. It additionally introduces a method for simulating tau neurofibrillary pathology, resulting in a more dramatic damage profile. Small-world connectivity is shown to have contrasting effects on capacity, retrieval time, and robustness to damage, whilst the use of more easily-obtained remote memories rather than recent memories for synaptic compensation is found to lead to rapid network damage.
|Type of Work:||Article|
|Date:||01 August 2011 (Publication)|
|School/Faculty:||Colleges (2008 onwards) > College of Engineering & Physical Sciences|
|Department:||Department of Computer Science|
|Subjects:||RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry|
QA75 Electronic computers. Computer science
|Institution:||University of Birmingham|
|Copyright Holders:||Institute of Electrical and Electronics Engineers|
Repository Staff Only: item control page