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Effects of compensation, connectivity and tau in a computational model of Alzheimer's Disease

Rowan, Mark (2011) Effects of compensation, connectivity and tau in a computational model of Alzheimer's Disease. Proceedings of the International Joint Conference on Neural Networks.

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Identification Number/DOI: 10.1109/IJCNN.2011.6033268

This work updates an existing, simplistic computational model of Alzheimer's Disease (AD) to investigate the behaviour of synaptic compensatory mechanisms in neural networks with small-world connectivity, and varying methods of calculating compensation. It additionally introduces a method for simulating tau neurofibrillary pathology, resulting in a more dramatic damage profile. Small-world connectivity is shown to have contrasting effects on capacity, retrieval time, and robustness to damage, whilst the use of more easily-obtained remote memories rather than recent memories for synaptic compensation is found to lead to rapid network damage.

Type of Work:Article
Date:01 August 2011 (Publication)
School/Faculty:Colleges (2008 onwards) > College of Engineering & Physical Sciences
Department:Department of Computer Science
Subjects:RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
QA75 Electronic computers. Computer science
Institution:University of Birmingham
Copyright Holders:Institute of Electrical and Electronics Engineers
ID Code:745
Refereed:YES
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