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A Two-Gene Balance Regulates Salmonella Typhimurium Tolerance in the Nematode Caenorhabditis elegans

Marsh, Elizabeth K. and van den Berg, Maaike C. W. and May, Robin C. (2011) A Two-Gene Balance Regulates Salmonella Typhimurium Tolerance in the Nematode Caenorhabditis elegans. PLoS ONE, 6 (3). e16839. ISSN 1932-6203

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URL of Published Version: http://dx.doi.org/10.1371/journal.pone.0016839

Identification Number/DOI: doi:10.1371/journal.pone.0016839

Lysozymes are antimicrobial enzymes that perform a critical role in resisting infection in a wide-range of eukaryotes. However, using the nematode Caenorhabditis elegans as a model host we now demonstrate that deletion of the protist type lysozyme LYS-7 renders animals susceptible to killing by the fatal fungal human pathogen Cryptococcus neoformans, but, remarkably, enhances tolerance to the enteric bacteria Salmonella Typhimurium. This trade-off in immunological susceptibility in C. elegans is further mediated by the reciprocal activity of lys-7 and the tyrosine kinase abl-1. Together this implies a greater complexity in C. elegans innate immune function than previously thought.

Type of Work:Article
Date:02 March 2011 (Publication)
School/Faculty:Colleges (2008 onwards) > College of Life & Environmental Sciences
Department:School of Biosciences
Subjects:R Medicine (General)
Institution:University of Birmingham
Copyright Holders:PLoS
ID Code:805
Refereed:YES
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