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Interleukin (IL)–12 and IL-23 Are Key Cytokines for Immunity against Salmonella in Humans

MacLennan, Calman A. and Fieschi, Claire and Lammas, David A and Picard, Capucine and Dorman, Susan E and Sanal, Ozden and MacLennan, Jenny M and Holland, Steven M and Ottenhoff, Tom H. M and Casanova, Jean-Laurent and Kumararatne, Dinakantha S (2004) Interleukin (IL)–12 and IL-23 Are Key Cytokines for Immunity against Salmonella in Humans. The Journal of Infectious Diseases, 190 (10). pp. 1755-1757. ISSN 0022-1899

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URL of Published Version: http://www.journals.uchicago.edu/doi/full/10.1086/425021

Identification Number/DOI: 10.1086/425021

Patients with inherited deficiency of the interleukin (IL)–12/IL-23–interferon (IFN)–g axis show increased susceptibility to invasive disease caused by the intramacrophage pathogens salmonellae and mycobacteria. We analyzed data on 154 patients with such deficiency. Significantly more patients with IL-12/IL-23–component deficiency had a history of salmonella disease than did those with IFN-g–component deficiency. Salmonella disease was typically severe, extraintestinal, and caused by nontyphoidal serovars. These findings strongly suggest that IL-12/IL-23 is a key cytokine for immunity against salmonella in humans and that IL-12/IL-23 mediates this protective effect partly through IFN-g–independent pathways. Investigation of the IL-12/IL-23–IFN-g axis should be considered in patients with invasive salmonella disease.

Type of Work:Article
Date:15 November 2004 (Publication)
School/Faculty:Schools (1998 to 2008) > School of Medicine
Department:Division of Immunity and Infection
Subjects:R Medicine (General)
Institution:University of Birmingham
Copyright Holders:University of Chicago Press
ID Code:88
Refereed:YES
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