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Deciphering the role of Epstein-Barr virus in the pathogenesis of T and NK cell lymphoproliferations

Fox, Christopher P and Shannon-Lowe, Claire and Rowe, Martin (2011) Deciphering the role of Epstein-Barr virus in the pathogenesis of T and NK cell lymphoproliferations. Herpesviridae, 2 (1). p. 8. ISSN 2042-4280

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URL of Published Version: http://dx.doi.org/10.1186/2042-4280-2-8

Identification Number/DOI: doi:10.1186/2042-4280-2-8

Epstein-Barr virus (EBV) is a highly successful herpesvirus, colonizing more than 90% of the adult human population worldwide, although it is also associated with various malignant diseases. Primary infection is usually clinically silent, and subsequent establishment of latency in the memory B lymphocyte compartment allows persistence of the virus in the infected host for life. EBV is so markedly B-lymphotropic when exposed to human lymphocytes in vitro that the association of EBV with rare but distinct types of T and NK cell lymphoproliferations was quite unexpected. Whilst relatively rare, these EBV-associated T and NK lymphoproliferations can be therapeutically challenging and prognosis for the majority of patients is dismal. In this review, we summarize the current knowledge on the role of EBV in the pathogenesis of these tumours, and the implications for treatment.

Type of Work:Article
Date:07 September 2011 (Publication)
School/Faculty:Colleges (2008 onwards) > College of Medical & Dental Sciences
Department:School of Cancer Studies
Subjects:R Medicine (General)
Institution:University of Birmingham
Copyright Holders:BioMed Central
ID Code:895
Refereed:YES
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